There are large potential therapeutic applications for this patent, including
- Men’s Erectile Dysfunction
- Woman’s Sexual Dysfunction
- Baldness/alopecia
- Raynaud’s syndrome
- Arthritis
- The drug is Alprostadil, an FDA approved drug that enhances blood flow.
- It is approved to treat erectile dysfunction in men, and to treat infants with congenital heart conditions.
- Alprostadil is currently administered by local injection or suppository.
- Madera has been awarded a US patent for a method of administering Alprostadil topically.
- Madera is focusing on the erectile dysfunction application first, because it has a faster FDA regulatory pathway and a large $4B+ target market with a significant unmet treatment need.
Madera is a patented topical application of an injected FDA approved drug
The Market
$4 BILLION CURRENT ED TREATMENT SALES EXCEED $4 BILLION AND ARE GROWING WITH AN AGING POPULATION
Market demand is estimated at more than 2x current levels. For many men, present treatments are not effective, or not allowed due to other health conditions, or are too expensive, painful, and uncomfortable to use.
- 40% Of men are affected by ED at age 40
- 70% Of men are affected by ED by age 70
Erectile Dysfunction
URETHRAL CREAM SUPPOSITORY
Effective, approved drug using the active ingredient in Madera
Fast acting, effective and safe Extremely unpleasant to use US pricing is $80 per dose
OTC AROUSAL ENHANCEMENT TOPICALS
External topicals and sprays Use evaporation/ organic volatiles to elicit a response
Requires a healthy male for effect
INJECTIONS
Estimated $300 - $500B market sales US and EU
Caverject® is the FDA approved injected version of Madera’s active drug $80 to $130 per dose in US.
PILLS
$2B sales market
Target market limited to healthy men without heart conditions or nerve damage Doesn’t work on 30-40% of men Many systemic side effects
DEVICES & IMPLANTS
$1.4B market sales
Devices and surgery can be expensive, socially awkward, often painful and desperate measures
Competitors
This product is under development and has not been approved for human use
Current ED treatments do not meet patient needs
- Pills like Viagra cannot be taken by men with heart conditions and are not effective on ED caused by prostate surgery nerve damage
- Viagra takes up to an hour to act, has many systemic side effects, and simply doesn't work for 30-40% of men
- The non-pill alternatives are painful and invasive measures with an unsatisfied user base
